Frontline Plus for dogs packaging with a Dalmatian dog on a purple and blue background
Dog being petted by a person with text about killing fleas and ticks on a gray background
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Woman walking a dog with text about trust over 20 years in pet care.
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FRONTLINE_Plus_for_Large_Dog_45_88_lbs_Flea_and_Tick_Treatment_6_Doses
for_Dogs_Large_Dog_45_88_lbs_Flea_and_Tick_Treatment_6_Doses
FRONTLINE Plus for Dogs Large Dog (45–88 lbs) Flea and Tick Treatment – 6 Doses
FRONTLINE Plus for Dogs Large Dog (45–88 lbs) Flea and Tick Treatment – 6 Doses
FRONTLINE Plus for Dogs Large Dog (45–88 lbs) Flea and Tick Treatment – 6 Doses

FRONTLINE Plus for Dogs Large Dog (45–88 lbs) Flea and Tick Treatment – 6 Doses

Regular price $75.00

FRONTLINE Plus for Dogs Large Dog (45–88 lbs) Flea and Tick Treatment – 6 Doses

FRONTLINE Plus for Dogs provides fast-acting, long-lasting protection against fleas, ticks, chewing lice, and mites. Specially formulated for large dogs weighing 45 to 88 pounds, this trusted treatment kills adult fleas, flea eggs, and larvae to break the flea life cycle and prevent future infestations.

Key Features

  • Active Ingredients: Fipronil (9.8%) and (S)-Methoprene (8.8%)

  • Fast-Acting & Long-Lasting: Begins working quickly and provides continuous protection for 30 days.

  • Waterproof Formula: Remains effective even after bathing or swimming, once dry after 24 hours.

  • Easy Monthly Application: Apply one dose directly to your dog’s skin between the shoulder blades once a month.

  • Comprehensive Protection: Kills fleas, flea eggs, flea larvae, ticks (including those that may transmit Lyme disease), and chewing lice.

Product Details

  • Manufacturer: Boehringer Ingelheim Animal Health

  • Brand: Frontline

  • Model Number: 72219

  • Size: 6 applicators (6-month supply)

  • Color Box: Purple (for Large Dogs 45–88 lbs)

  • Dimensions: 5.75 x 1 x 4.5 inches

  • Weight: 0.2 ounces

  • For Use On: Dogs 8 weeks or older, weighing 45–88 lbs

How to Use

  1. Remove Applicator: Use scissors to separate one blister and cut along the dotted line. Peel back the foil to remove.

  2. Open Applicator: Hold upright with foil facing you and snap the tip.

  3. Apply Treatment: Part your dog’s hair between the shoulder blades, apply the entire contents directly to the skin in one spot, and avoid touching the area until dry.

Apply once every 30 days for continuous flea and tick control.

Safety Information

For external use only. Do not use on puppies under 8 weeks old or weighing less than 5 lbs. Avoid ingestion or contact with treated areas until dry. Individual sensitivities are rare but possible with any pesticide product.

Trusted Protection

With over 20 years of proven performance and trusted by veterinarians and pet owners alike, FRONTLINE Plus continues to be one of the top-rated choices for effective flea and tick prevention for dogs.
FRONTLINE Plus for Dogs Large Dog (45–88 lbs) Flea and Tick Treatment – 6 Doses
FRONTLINE Plus for Dogs Large Dog (45–88 lbs) Flea and Tick Treatment – 6 Doses

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